Endothelial dysfunction in adipose triglyceride lipase deficiency: role of perivascular adipose tissue
نویسندگان
چکیده
منابع مشابه
Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an importa...
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BACKGROUND AND PURPOSE Adipose triglyceride lipase (ATGL) has been identified as a rate-limiting enzyme of mammalian triglyceride catabolism. Deletion of the ATGL gene in mice results in severe lipid accumulation in a variety of tissues including the heart. In the present study we investigated cardiac function in ATGL-deficient mice and the potential therapeutic effects of the PPARα and γ agoni...
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Systemic deletion of the gene encoding for adipose triglyceride lipase (ATGL) in mice leads to severe cardiac dysfunction due to massive accumulation of neutral lipids in cardiomyocytes. Recently, impaired peroxisome proliferator-activated receptor α (PPARα) signaling has been described to substantially contribute to the observed cardiac phenotype. Disturbances of the ubiquitin-proteasome syste...
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Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance. Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and insulin sensitivity despite triacylglycerol accumulation in multiple tissues. To determine the molecular mechanisms for...
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STIMULATED INSULIN SECRETION Marie-Line Peyot, Claudiane Guay, Martin G. Latour, Julien Lamontagne, Roxane Lussier, Marco Pineda, Neil B. Ruderman, Guenter Haemmerle, Rudolf Zechner, Érik Joly, S. R. Murthy Madiraju, Vincent Poitout and Marc Prentki Molecular Nutrition Unit and the Montreal Diabetes Research Center, CRCHUM; Departments of Nutrition and Medicine, University of Montreal, Montreal...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2013
ISSN: 2050-6511
DOI: 10.1186/2050-6511-14-s1-p45